Hand-foot-mouth disease is a common infectious disease occurred in children caused by enteroviral infection. There are more than 20 kinds (types) of enteroviruses associated with hand-foot-mouth disease, among which the Coxsackie virus group A type 16 (CV-A16) and the Enterovirus type 71 (EV-A71) are the most common.

In epidemic phase, influenza is easy to diagnose in combination with clinical symptoms. However, for definite diagnosis or epidemiology surveillance, laboratory test is necessary, mainly including serological diagnosis and rapid diagnostic test.

The clinical manifestations of hand, foot and mouth disease are complex and diverse. It mostly occurs in children under 5 years of age. It manifests as mouth sore, anorexia, low fever, small herpes or small ulcers on hands, feet, mouth and other parts. Most children heal on their own in about a week. A few children can cause myocarditis, pulmonary edema, and Complications such as bacterial meningoencephalitis.